What if AST ALT ratio is high?
An AST/ALT ratio higher than one (where the AST is higher than ALT) is suggestive of cirrhosis. An AST/ALT ratio higher than 2:1 (where the AST is more than twice as high as the ALT) is suggestive of alcoholic liver disease.
Why are ALT and AST increased in hepatitis?
Hepatocellular injury will typically cause elevated transaminases (AST/ALT) that are released into the serum as a result of liver cell injury or death. A cholestatic injury will cause an elevated alkaline phosphatase and bilirubin out of proportion to the level of transaminitis.
What causes elevated levels of AST and Alt?
Common causes of elevated ALT and AST are viral liver infections, alcohol abuse, cirrhosis (from any chronic causes), and more. Normal levels of AST (SGOT) is about 5-40 units/liter of serum. Elevated levels of AST and ALT may signify the level of liver damage in a person.
What could be causing elevated levels of AST and ALT levels?
The most common diseases causing abnormally elevated ALT and AST are acute viral hepatitis, such as hemochromatosis (a genetic condition causing long standing liver damage due to iron build up in the liver), and diminished blood flow to the liver (from shock or heart failure).
What are dangerous Alt and AST levels?
There is no danger level for SGOT. However, more than 200 is a cause of concern. The extent of liver damage is directly proportional to the SGOT level. However, it is common to have values more than 2000-3000 in viral infection of liver, with complete recovery.
What causes elevation in Alt and AST levels?
As fat increases in the liver, it results in damage to the liver cells . This damage is seen in the serum (bloodstream) as an elevation in serum levels of AST and ALT. If the diet is not changed or if insulin resistance is not managed then this fat accumulation will eventually cause permanent and chronic damage to the liver.