What covers tigecycline?

What covers tigecycline?

Coverage includes many multidrug-resistant strains of gram-positive organisms, such as MRSA and MRSE, penicillin-resistant Streptococcus pneumoniae, and VRE species. Tigecycline has also shown activity against organisms that have developed resistance to tetracycline via various mechanisms.

How do you give tigecycline?

Tigecycline is administered only by intravenous infusion over 30 to 60 minutes (see sections 4.4 and 6.6). Tigecycline should be preferably administered over a 60-minute length of infusion in paediatric patients (see section 4.4).

Does tigecycline need to be refrigerated?

Once mixed, it may be stored at room temperature for up to 24 hours (up to six hours in the vial and the remaining time in the intravenous bag). It may also be refrigerated at 2 C – 8 C (36 F – 46 F) for up to 48 hours in an intravenous bag after mixing.

What is tigecycline used for?

Tigecycline injection used to treat certain serious infections including community acquired pneumonia (a lung infection that developed in a person who was not in the hospital), skin infections, and infections of the abdomen (area between the chest and the waist).

How expensive is tigecycline?

Cost. Tigecycline is supplied as a 50 mg vial for reconstitution. The average wholesale price (AWP) for treatment with tigecycline is $162.83 on day 1 (including the loading dose of 100 mg and a 50 mg dose 12 h later) and $108.55 on subsequent treatment days (based on a dose of 50 mg every 12 h).

When do you give tigecycline?

The recommended dosage regimen for TYGACIL is an initial dose of 100 mg, followed by 50 mg every 12 hours. Intravenous infusions of TYGACIL should be administered over approximately 30 to 60 minutes every 12 hours.

Is tygacil expensive?

The cost for Tygacil intravenous powder for injection 50 mg is around $1,240 for a supply of 10 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

Is amikacin a strong antibiotic?

Amikacin is an antibiotic that fights bacteria. Amikacin is used to treat severe or serious bacterial infections. Amikacin may also be used for purposes not listed in this medication guide.

What bacteria does tetracycline treat?

Tetracyclines are broad-spectrum agents, exhibiting activity against a wide range of gram-positive and gram-negative bacteria, atypical organisms such as chlamydiae, mycoplasmas, and rickettsiae, and protozoan parasites.

What is tigecycline a derivative of?

Tigecycline is the first member of a new class of antibacterial agents, the glycylcyclines. It is a derivative of minocycline. This group has been specifically developed to overcome the two major mechanisms of tetracycline resistance (ribosomal protection and efflux).

How expensive is daptomycin?

The cost for daptomycin intravenous powder for injection 500 mg is around $31 for a supply of 1 powder for injection, depending on the pharmacy you visit….Intravenous Powder For Injection.

Is Tygacil expensive?

How much Tigecycline is in a vial of Tygacil?

TYGACIL is an orange lyophilized powder or cake. Each TYGACIL vial contains 50 mg tigecycline lyophilized powder for intravenous infusion. The product does not contain excipients or preservatives.

How old do you have to be to take tigecycline injection?

Tigecycline for injection is indicated in patients 18 years of age and older for the treatment of community-acquired bacterial pneumonia caused by susceptible isolates of Streptococcus pneumoniae (penicillin-susceptible isolates), including cases with concurrent bacteremia, Haemophilus influenzae, and Legionella pneumophila.

When to use tigecycline after a reconstitution?

If the storage conditions exceed 25°C (77°F) after reconstitution, tigecycline should be used immediately.

What kind of testing do I need for tigecycline?

Isolates yielding MIC results suggestive of “Nonsusceptible” category should be submitted to reference laboratory for further testing.