What is the pKa of imidazole?

Imidazole is an important intracellular buffer because it is a building block for proteins and enzymes and because it has a pKa (at 37°C) of 6.8 (close to intracellular pH).

What is the PKB of imidazole?

As an acid, the pKa of imidazole is 14.5, making it less acidic than carboxylic acids, phenols, and imides, but slightly more acidic than alcohols. The acidic proton is the one bound to nitrogen. Deprotonation gives the imidazolide anion, which is symmetrical.

What is the use of 2 4 5 triphenyl imidazole?

SYNTHESIS OF 2, 4, 5- TRIPHENYL IMIDAZOLE DERIVATIVES AND BIOLOGICAL EVALUATION FOR THEIR ANTIBACTERIAL AND ANTI-INFLAMMATORY ACTIVITY. On the basis of various literature survey, imidazole derivatives show various activity such as antimicrobial, anti-inflammatory, analgesic, antitubercular, anticancer etc.

Why is imidazole a base?

Imidazole is an aromatic ring found in many biological molecules. One of its nitrogen atoms resembles that of pyrrole, and is not basic. The second nitrogen atom, which is structurally similar to the nitrogen atom of pyridine, acts as a base.

What is the pKa of piperidine?

about 10
5. (10 points) The conjugate acid of morpholine has a pKa of about 8, while the conjugate acid of piperidine has a pKa of about 10.

What does imidazole mean?

: a white crystalline heterocyclic base C3H4N2 that is an antimetabolite related to histidine broadly : any of various derivatives of this.

How do you make triphenyl imidazole?

A simple one-pot procedure for the preparation of 2,4,5-triphenyl imidazole derivatives is pre- sented. The procedure involves the lead tetraacetate oxidation of 1,2-diols to give aldehydes in situ, which then undergo a three-component reaction with benzil and ammonium acetate to yield the imidazole derivatives.

Which is least basic compound?

NI3 is least basic because Iodine has vacant d orbital hence it can accept lone pair of electrons from Nitrogen and help in back bonding. Also, basicity decreases down the group and in this manner as well NI3 is less basic than any other given compounds.

What are the pKa values of acetonitrile?

pKa values of 231 acids in acetonitrile, ranging from hydrogen iodide (2.8) and indole (32.57) and covering almost 30 orders of magnitude. This is the revised and significantly extended version of our pKa scale of acids in MeCN.

How does imidazole play a role in intracellular buffering?

Imidazole-based histidine compounds play a very important role in intracellular buffering. Histidine can be decarboxylated to histamine, which is also a common biological compound. Histamine can cause urticaria (hives) when it is produced during allergic reaction.

How is imidazole produced in a photolysis reaction?

Imidazole can be synthesized by the photolysis of 1-vinyltetrazole. This reaction will give substantial yields only if the 1-vinyltetrazole is made efficiently from an organotin compound, such as 2-tributylstannyltetrazole. The reaction, shown below, produces imidazole when R 1 = R 2 = R 3 = hydrogen.

Which is the correct formula for the compound imidazole?

Imidazole is an organic compound with the formula C 3N 2H 4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and has non-adjacent nitrogen atoms.