What is K103N mutation?

K103N is a non-polymorphic mutation that causes high-level reductions in NVP and EFV susceptibility. 103R. Other. K103R is a polymorphic mutation that alone has no effect on NNRTI susceptibility. However, in combination with V179D, it reduces NVP and EFV susceptibility about 15-fold.

What are the most common two pathways of resistance with raltegravir?

Two primary resistance pathways associated with raltegravir treatment failures in the BENCHMRK-1 and BENCHMRK-2 studies have been described, as follows :

  • Q148K/R/H (25-fold decrease in susceptibility)
  • N155H (10-fold decrease in susceptibility)

Which of the following belongs to class Nnrti?

Current status. Five drugs in the class of NNRTIs have been approved by regulatory authorities. These are the first generation NNRTIs nevirapine, delavirdine and efavirenz and the next generation NNRTIs etravirine, and rilpivirine.

What is K65R?

K65R is a relatively rare drug resistance mutation (DRM) selected by the NRTIs tenofovir, didanosine, abacavir and stavudine and confers cross-resistance to all NRTIs except zidovudine.

How does reverse transcriptase inhibitors work?

Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.

What are examples of Nnrti?

What are the FDA-approved NNRTIs and their side effects?

  • Delavirdine (Rescriptor)
  • Efavirenz (Sustiva)
  • Etravirine (Intelence)
  • Nevirapine (Viramune, Viramune XR)
  • Rilpivirine (Edurant)
  • Doravirine (Pifeltro)

Which drugs are NNRTIs?

List of NNRTIs:

Drug Name Avg. Rating Reviews
Sustiva (Pro) Generic name: efavirenz 6.1 6 reviews
Viramune (Pro) Generic name: nevirapine 4.5 2 reviews
Intelence (Pro) Generic name: etravirine 6.8 2 reviews
Viramune XR Generic name: nevirapine No reviews

What is genotypic resistance?

Genotypic resistance testing examines the genetic structure (genotype) of a patient’s HIV. A blood sample is taken from the patient, and the HIV is analyzed for the presence of specific genetic mutations that are known to cause resistance to specific drugs.

Is the K103N mutation associated with decreased rilpivirine activity?

The K103N mutation, on its own, has not been associated with decreased activity of rilpivirine in vitro, but clinical data are lacking. (2,3)

What are the implications of resistance to rilpivirine?

Resistance to rilpivirine is associated with the selection of 1 or more resistance mutations. Implications of resistance to rilpivirine for treatment with other antiretrovirals

Which is NNRTI resistance mutation does K101E occur in?

K101E is a nonpolymorphic mutation selected in patients receiving each of the NNRTIs except possibly DOR for which few data are available ( 22, 23, 30, 4 ). K101E usually occurs in combination with other NNRTI-resistance mutations.

How does k101p affect susceptibility to NVP and EFV?

K101P is a nonpolymorphic two base-pair mutation selected in persons receiving each of the NNRTIs except possibly DOR for which few data are available ( 23, 30, 4 ). It reduces NVP, EFV, and RPV susceptibility by >50-fold and ETR susceptibility by ~5-fold ( 32, 28, 2, 33, 34, 10 ).