What is a prothrombin gene mutation?
The Prothrombin Gene Mutation is a change in the gene that controls a blood clotting protein that circulates in the blood called prothrombin. This particular gene change leads to an increase in the level of this protein in the blood.
Is prothrombin mutation a blood disorder?
Prothrombin gene mutation is a blood clotting disorder, not a disease. It causes the body to make too much prothrombin, which makes the blood more likely to clot. Blood clots in your lungs or the deep veins of your legs can be dangerous.
What is the G20210A mutation?
Prothrombin G20210A is a genetic condition that increases the risk of blood clots including from deep vein thrombosis, and of pulmonary embolism. One copy of the mutation increases the risk of a blood clot from 1 in 1,000 per year to 2.5 in 1,000. Two copies increases the risk to up to 20 in 1,000 per year.
Is Factor V Leiden a prothrombin gene mutation?
Factor V Leiden and prothrombin 20210 (PT 20210 or Factor II mutation) are genetic mutations that are associated with an increased risk of developing inappropriate blood clots.
How serious is prothrombin gene mutation?
Having the prothrombin mutation increases the risk of developing a DVT (a blood clot in the deep veins, typically the legs) and/or PE (blood clot that travels to the lungs). DVTs are dangerous because they can damage the veins, leading to pain and swelling, and sometimes to disability.
How common is prothrombin gene mutation?
A change in the prothrombin gene is present in 2-4% (or 1 in 50 to 1 in 25) of Caucasians, and is more common in individuals of European ancestry. In the United States, approximately 0.4% (about 1 in 250) of African Americans also have the mutation. Prothrombin G20210A mutation is rare in other groups.
How common is prothrombin mutation?
Can you have a baby with prothrombin gene mutation?
Apart from blood clots, prothrombin mutations are associated with an increased risk of complications during pregnancy. These complications include: pregnancy loss (miscarriage or stillbirth) preeclampsia (increased blood pressure and protein in the urine during pregnancy)
What is the other name for prothrombin?
Prothrombin: A coagulation (clotting) factor that is needed for the normal clotting of blood. A cascade of biochemical events leads to the formation of the final clot. In this cascade, prothrombin is a precursor to thrombin. Prothrombin is also known as thrombinogen and, in medical jargon, as pro.
Can aspirin dissolve a blood clot?
Working With Your Doctor for Vein Health In some cases, aspirin will not provide enough protection. Additionally, it may not work to dissolve a clot properly. Instead, it may be better as a preventative measure after a clot has been thoroughly dissolved by another medication.
What are the risks of prothrombin G20210A mutation?
Prothrombin G20210A. Prothrombin G20210A is a genetic condition that increases the risk of blood clots including deep vein thrombosis and pulmonary embolism. One copy of the mutation increases the risk of a blood clot from 1 in 1,000 per year to 2.5 in 1,000.
Is the factor II mutation the same as prothrombin?
Terminology. Because prothrombin is also known as factor II, the mutation is also sometimes referred to as the factor II mutation or simply the prothrombin mutation; in either case, the names may appear with or without the accompanying G20210A location specifier (unhelpfully, since prothrombin mutations other than G20210A are known).
Can a mutation in prothrombin cause VTE?
However, Prothrombin G20210A mutation was found to cause elevated levels of blood prothrombin (by one-third above normal; 133%), which is more than the extra 15% needed to develop VTE.
What should you avoid if you have prothrombin mutation?
Oral contraceptives should generally be avoided in women with the mutation as they increase the thrombotic risk.