What does A1298C mutation mean?
The A1298C mutation, like the C677T mutation, results in a decrease in MTHFR activity that is more pronounced in the homozygous (CC) than in the heterozygous (AC) or normal (AA) states, and does not result in a thermolabile protein.
What is C677T and A1298C?
There are two common MTHFR mutations, known as C677T and A1298C. The term MTHFR stands for methylenetetrahydrofolate reductase. MTHFR is an enzyme that breaks down the amino acids’ homocysteine and folate. Homocysteine is an amino acid that works to maintain the body’s cells.
How common is A1298C mutation?
About 30 to 40 percent of the American population may have a mutation at gene position C677T. Roughly 25 percent of people of Hispanic descent, and 10 to 15 percent of Caucasian descent, are homozygous for this variant. A1298C.
How is MTHFR A1298C treated?
Natural treatments for MTHFR mutation symptoms
- Consume more folate and vitamin B12. Consuming more folate in your diet may aid with methylation.
- Support detoxification.
- Minimize alcohol intake.
- Manage your stress with lifestyle changes.
- Check your supplements.
- Heal any underlying digestive issues.
How common is MTHFR mutation?
How common are MTHFR variants? MTHFR variants are found in people worldwide. In some ethnicities, the chance to have at least one MTHFR variant is as high as 50%. Between 10%-15% of the Caucasian population and more than 25% of the Latino population have variants in both copies of the MTHFR gene.
How is MTHFR treated?
Treatment of MTHFR deficiency involves taking betaine, folinic acid, Vitamins B6 and B12, methionine, and methyltetrahydrofolate supplements. If MTHFR deficiency is diagnosed early and betaine treatment is started right away, affected infants have a much better developmental outcome.
Can MTHFR cause autoimmune disorders?
1 The MTHFR mutation is also believed to predispose a person to certain cancers, birth defects, and autoimmune diseases.
What is the difference between a C677T and A1298C mutation?
When their results come back positive they are faced with one or more types of mthfr gene mutations that have their own code. Most often these codes look like this: MTHFR Gene Mutation (C677T) and or MTHFR Gene Mutation (A1298C)
How does the gene mutation c667t affect your health?
How much the gene mutation C667T will affect your health, for example: MTHFR C677T heterozygous = 30-40% loss of mthfr function MTHFR C677T homozygous = 60-70% loss of mthfr function Problems with C677T gene mutations The problems experienced by the C677T gene mutation are more likely to have elevated homocysteine.
What happens if you have a mutation in MTHFR A1298C?
Updated: Jan 23, 2020. If you have a mutation in your MTHFR A1298C gene, your body is impacted very differently from a mutation at MTHFR C677T or MTHFR 03. Most people mean MTHFR C677T when they refer to MTHFR, because it is a common mutation and it has a major impact. But MTHFR A1298C is significant also.
What is the difference between MTHFR and C677T mutations?
MTHFR C677T heterozygous = 30-40% loss of mthfr function MTHFR C677T homozygous = 60-70% loss of mthfr function Problems with C677T gene mutations The problems experienced by the C677T gene mutation are more likely to have elevated homocysteine.