What are the manufacturing defect of the capsule?

CAPSULE SHELL PRODUCTION PROCESS

DEFECTS PROCESS RELATED CAUSES
Bubbles Improper vacuum or duration of the gelatin bubbles extraction process.
Damaged print Improper ink viscosity and applying pressure, uneven flow of the ink, clogged ink jets, incomplete drying of ink etc.

What is telescopic defect in capsule?

Telescoping. This defect occurs when the cap and body misalign and the capsule body splits and a portion of it covers the cap. To eliminate this defect, make sure all the capsules are perfectly round. Also check the alignment of the cap and body bushings, or segments, using a gauge designed for that purpose.

How do you manufacture hard gelatin capsules?

Manufacture of Hard Gelatin Capsules

  1. Step 1: Preparation of the gelatin solution (dipping solution)
  2. Step 2: Dip-coating the gelatin solution on to metal pins (moulds)
  3. Step 3: Rotation of the dip-coated pins.
  4. Step 4: Drying of the gelatin-coated pins.
  5. Step 5: Stripping and trimming.

What substance is added to the manufacturing of hard gelatin capsule to prevent decomposition?

A. The empty hard capsules are made from gelatin and sugar, colorant and opacifying agent such as titanium dioxide, and 0.15% sulfur dioxide is permitted by the USP to prevent decomposition of gelatin during manufacture.

How many types of capsules are there?

This outer shell is broken down in the digestive tract and the medication is absorbed into the bloodstream and then distributed and metabolized in much the same way as medication from a tablet. There are two main types of capsules: hard shelled and soft gel.

What is the smallest size of capsule?

Size 5. #5 capsules are the smallest standard capsule size.

What can be filled in a hard gelatin capsule?

Filling of liquids/semisolid formulations into hard gelatin capsules

Lipophilic excipients Vegetable oils e.g., Peanut oil, Castor oil, Olive oil, Fractionated coconut oil, Corn oil, Sesame oil, Hydrogenated vegetable oil, Soybean oil
Esters e.g., Glycerol Stearate, Glycol Stearate, Isopropyl myristate, Ethyl oleate

What is hard gelatin capsule used for?

Uses of Methoxsalen Hard-Gelatin Capsules: It is used to treat psoriasis. It is used to treat a type of lymphoma that affects the skin. It is used to treat white patches on your skin (vitiligo).

Do hard gelatin capsules dissolve in water?

Therefore, in general, it can dissolve quickly in the body temperature environment. When the environment is “dry”, the water content of the gelatin capsule exceeds 10%. It increases rapidly when soaked in a humid environment. It takes about 10-20 minutes for the matrix to soften, twist and decompose.

What are the most common hard gel capsule defects?

In the table below, we have prepared an overview of the most common visual hard gel capsule defects we see in our daily work. As you’ll notice, the defects are divided into two groups according to their source, which can be in capsule shell manufacturing or filling process.

Are there any problems with hard gelatin capsules?

In addition, chemical interactions between the components can lead to bioavailability or stability problems.

What are the defects in the capsule closing process?

Some of the most troublesome filled capsule defects occur in the capsule closing process, and are termed splits, telescoped capsules, folds and cap tucks. These defects occur during capsule closing, as the edges of the cap and body collide; in many cases causing product leakage.

Why are gelatin capsules supposed to be film coated?

Tablets for capsule filling are normally film-coated to prevent dust generation and are sized so that they can fall freely into the capsule body but without turning on their sides.