Does Lynch syndrome cause polyps?

Individuals with Lynch syndrome may develop a few colorectal polyps, called adenomas, in the colon or rectum. If these polyps are not detected and removed, they could develop into a cancer. Having regular screening colonscopies is important for detecting and removing these polyps.

What are the stages of colon polyps?

Stage 0 – The cancer is found only in the innermost lining of the rectum or colon. Stage I – The cancer has not spread beyond the inner wall of the rectum or colon. Stage II – The cancer has spread into the muscle layer of the rectum or colon. Stage III – The cancer has spread to at least one lymph node in the area.

Does colon cancer start with polyps?

Most colorectal cancers start as a growth on the inner lining of the colon or rectum. These growths are called polyps. Some types of polyps can change into cancer over time (usually many years), but not all polyps become cancer. The chance of a polyp turning into cancer depends on the type of polyp it is.

What is anti EGFR therapy?

As targeted biologic agents, anti-EGFR therapies provide a treatment alternative for patients who cannot tolerate or who are otherwise ineligible for chemotherapy. Anti-EGFR therapy offers an important treatment benefit in refractory disease.

Does vitamin D help prevent colon polyps?

Several studies confirmed that increasing vitamin D3 lowers colon cancer incidence, reduces polyp recurrence, and that sufficient levels of vitamin D3 are associated with better overall survival of colon cancer patients.

What inhibits EGF?

Two classes of EGFR inhibitors are in current use: the monoclonal antibodies (cetuximab, panitumumab, and matuzumab) that target the extracellular ligand-binding domain and small-molecule tyrosine kinase inhibitors (gefitinib, erlotinib, lapatinib, and afatinib) which target intracellular domain [1, 2].

Can vitamin D deficiency cause colon polyps?

Analysis of data from a large trial has found evidence that using calcium supplements — with and without vitamin D — may raise the risk of developing certain types of polyp, or precancerous growths, in the colon or rectum up to 10 years after starting to take supplements.