What is the role of MMP?

Function. The MMPs play an important role in tissue remodeling associated with various physiological or pathological processes such as morphogenesis, angiogenesis, tissue repair, cirrhosis, arthritis, and metastasis. MMP-2 and MMP-9 are thought to be important in metastasis.

Is MMPs a collagenase?

In bone, MMP-1 is secreted by stromal fibroblasts, osteoblasts, and osteoclasts. Only the collagenases (MMP-1 and MMP-8) cleave native undenatured collagen at neutral pH. The cleavage is site specific at a single locus in the alpha 1(I) chain between Gly775/Ile776.

What are MMPs in dentistry?

Matrix metalloproteinases (MMPs) are a group of more than 25 secreted and membrane bound enzymes that represent class of enzymes responsible for degradation of pericellular substrates. They have been isolated from dentine, odontoblasts, pulp and periapical tissue.

How are MMPs activated?

The MMP activation by reactive oxygen is driven through preferential oxidation of the thiol–zinc interaction and autocatalytic cleavage, followed by enzyme inactivation with extended exposure by modification of amino acids critical for catalytic activity, as shown in vitro for MMP-7 [30].

What MMP-2 9?

Matrix metalloproteinases (MMPs) are important components of extracellular matrix proteasome and affect the remodeling and degradation of extracellular matrix greatly 9. MMP-2 and MMP-9 express in CNS and have multiple functions.

What are MMP 2 and MMP 9?

Gelatinases (matrix metalloproteinase-2 and -9) are enzymes from the matrix metalloproteinases (MMPs) family, which are associated with collagen degradation. MMP-2 is capable of cleaving gelatine, types I and IV collagens, while MMP-9 is incapable of direct proteolysis of collagen I and digests collagen type IV.

What is pro MMP?

Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade. Exp Cell Res.

What causes MMP-13?

Clinical investigation revealed that patients with articular cartilage destruction have high MMP13 expression [5], suggesting that increased MMP13 may be associated with cartilage degradation.